Inclusive Polygenic Scores (iPGS)


Admixed individuals offer unique opportunities to address limited transferability in polygenic scores (PGS), given the substantial trans-ancestry genetic correlation in many complex traits. However, they are rarely considered in PGS training, given the challenges in representing ancestry-matched linkage-disequilibrium reference panels for admixed individuals. We developed inclusive PGS (iPGS), a PGS training strategy to capture ancestry-shared genetic effects by finding the exact solution for penalized regression on individual-level data, thus naturally applicable to admixed individuals.


We host the results from the following studies. You may learn more about our iPGS browser here.

Browse iPGS models from our publication

Here, we present iPGS models for 60 hematological and anthropometric traits in UK Biobank described in the following study: